Season
- Season 16 2008-09-02
- Season 15 2007-09-04
- Season 14 2006-09-05
- Season 13 2005-09-06
- Season 12 2004-08-31
- Season 11 2003-09-03
- Season 10 2002-09-03
- Season 9 2001-09-04
- Season 8 2000-09-05
- Season 7 1999-09-07
- Season 6 1998-09-15
- Season 5 1997-09-09
- Season 4 1996-09-17
- Season 3 1995-09-11
- Season 2 1994-09-12
- Season 1 1993-09-13
- Season 0 1998-09-16
Episode
- Episode 1: Jon Lovitz, Wilmer Valderrama, Jet
- Episode 2: Gary Sinise, Seth Green, Tanya Streeter
- Episode 3: David Spade, Sara Rue, Jim Gaffigan
- Episode 4: Michael Caine, Jason Biggs, Joss Stone
- Episode 5: Christina Ricci, Michael Rapaport, The Folksmen
- Episode 6: Charlie Sheen, Scarlett Johansson, My Morning Jacket
- Episode 7: Kelsey Grammer, Craig Bierko, Greg Giraldo
- Episode 8: Kevin James, Teri Polo, Ken Burns
- Episode 9: Whoopi Goldberg, Rosario Dawson, Eastmountainsouth
- Episode 10: Diane Lane, Wanda Sykes, Jonny Lang
- Episode 11: The Rock, Isaac Mizrahi, Robert Randolph & The Family Band
- Episode 12: Alec Baldwin, Vanessa Marcil, Rancid
- Episode 13: Val Kilmer, Carmen Electra, Todd Barry
- Episode 14: Jack Black, Christopher Walken, Staind
- Episode 15: Lisa Kudrow, Jeremy Piven, Grandaddy
- Episode 16: Kevin Bacon, Vivica A. Fox, The Del McCoury Band
- Episode 17: Lucy Liu, Michael Moore, Gov't Mule
- Episode 18: Uma Thurman, Josh Lucas, North Mississippi All-stars
- Episode 19: Gwyneth Paltrow, Philip Seymour Hoffman, Howie Day
- Episode 20: Tim Robbins, Natasha Henstridge, Kaki King
- Episode 21: David Arquette, Gina Gershon, Béla Fleck and the Flecktones
- Episode 22: Norm MacDonald, Laura Prepon, Triumph the Insult Comic Dog
- Episode 23: Al Franken, Courtney Thorne-Smith, The Thrills
- Episode 24: Quentin Tarantino, Molly Sims, Chuck Palahniuk
- Episode 25: James Caan, David Cross, Greg Behrendt
- Episode 26: Patrick Stewart, Regina Hall, The Strokes
- Episode 27: Laurence Fishburne, Steven R. Schirripa, The Polyphonic Spree
- Episode 28: Will Ferrell, Chloë Sevigny, Sarah Vowell
- Episode 29: Darrell Hammond, Shannen Doherty, Joshua Bell
- Episode 30: Ice-T, Jenna Elfman, The Strokes
- Episode 31: Brendan Frasier, Marg Helgenberger, Ron Isley & Burt Bacharach
- Episode 32: Dolly Parton, Steve Irwin
- Episode 33: Russell Crowe, Alicia Silverstone, Andrew W.K.
- Episode 34: William H. Macy, Heidi Klum, The Strokes
- Episode 35: Elvis Costello, Eliza Dushku
- Episode 36: Billy Bob Thornton, Nick Lachey, Rob Krueger
- Episode 37: Lauren Graham, Steve Harvey, Dashboard Confessional
- Episode 38: Ron Howard, John Tesh, The Strokes
- Episode 39: Zach Braff, Billy Connolly, The Brian Setzer Orchestra
- Episode 40: Bernie Mac, Ben Chaplin, Thursday
- Episode 41: Brian Williams, Maggie Gyllenhaal, Jim Gaffigan
- Episode 42: Jude Law, Maggie Gyllenhaal, Michelle Branch
- Episode 43: Greg Kinnear, Bob Odenkirk, Tom Shales
- Episode 44: Matt Damon, Kevin Pollack, Randy Newman
- Episode 45: Kelly Ripa, Emma Bolger, Tony Bennett
- Episode 46: Elijah Wood, Estella Warren, Liz Phair
- Episode 47: Jennifer Connelly, Lewis Black, Sam Goldstein
- Episode 48: Natalie Portman, Bill O'Reilly, Patty Loveless
- Episode 49: Julia Stiles, Marc Maron. Mitch Hedberg
- Episode 50: Ian McKellen, Petra Nemcova, The Stills
- Episode 51: Tom Brokaw, Gary Sheffield, John Mayer with Buddy Guy and Double Trouble
- Episode 52: Jarod Miller, Amy Sedaris, Moby
- Episode 53: Ethan Hawke, George Wendt, Natalie MacMaster
- Episode 54: Tyra Banks, Andy Serkis, Los Lonely Boys
- Episode 55: Benicio Del Toro, Richard Lewis, Maroon 5
- Episode 56: Ben Stiller, Sarah Ferguson, Rich Hall
- Episode 57: Nathan Lane, Susie Essman, The Bouncing Souls
- Episode 58: Dave Chappelle, Jerry Orbach, The Candy Butchers
- Episode 59: Donald Trump, Jeff Garlin, Brian Kiley
- Episode 60: Ashton Kutcher, Kristin Kreuk, Rickie Lee Jones
- Episode 61: Topher Grace, Jack Osbourne, Jim McMullan
- Episode 62: Al Roker, Mischa Barton, Mindy Smith
- Episode 63: Matt Lauer, Tom Cavanagh, Paul Teutul, Paul Teutul Jr., & Mikey Teutul
- Episode 64: Megan Mullally, Harry Connick Jr.
- Episode 65: Drew Barrymore, Paul Rudd, The Walkman
- Episode 66: Mike Myers, Ron James (in Toronto)
- Episode 67: Michael J. Fox, Ken Capling, Nickelback (in Toronto)
- Episode 68: Adam Sandler, Stompin' Tom Connors (in Toronto)
- Episode 69: Jim Carrey, Eric McCormack, Barenaked Ladies (in Toronto)
- Episode 70: Meg Ryan, "Queer Eye" Guys, The Shins
- Episode 71: Kristen Davis, Omar Epps, The Holmes Brothers
- Episode 72: James Spader, Ruben Studdard, Kenny Chesney
- Episode 73: Walter Cronkite, Fred Armisen, Ben Harper
- Episode 74: Damon Wayans, Paulie Litt, Al Green
- Episode 75: Andy Garcia, Brittany Daniel, Brini Maxwell
- Episode 76: Samuel L. Jackson, James Carville, Van Hunt
- Episode 77: Barbara Walters, Grant Rosenmeyer, Grant Lee Philips
- Episode 78: Andy Dick, Clyde Peeling, Wheat
- Episode 79: Snoop Dogg, Paul Bettany, Mr. Geography
- Episode 80: Michael Imperioli, Kenan Thompson, Tom Jones
- Episode 81: Ben Stiller, Owen Wilson, Meredith Vieira, Cee-lo
- Episode 82: Liv Tyler, Juliette Lewis, Norah Jones
- Episode 83: Jeff Goldblum, Omarosa Stallworth, Sarah McLachlan
- Episode 84: Elijah Wood, Rachel Dratch, B. J. Novak
- Episode 85: Frankie Muniz, Big Show, Ollabelle
- Episode 86: Edie Falco, Mayor Jason West, The Allman Brothers Band
- Episode 87: Carson Daly, Portia de Rossi, James Lipton
- Episode 88: Kate Winslet, Jamie Lynn DiScala, The Living End
- Episode 89: Ethan Hawke, Neil Young, Omid Djalili
- Episode 90: Bob Costas, Brian Posehn, Toby Lightman
- Episode 91: Minnie Driver, Chris Klein, Usher
- Episode 92: Al Frankin, Vivica A. Fox, Scotty Nguyen
- Episode 93: The Rock, Colin Quinn, The Sleepy Jackson
- Episode 94: Johnny Knoxville, Elisha Cuthbert, The Distillers
- Episode 95: Lorraine Bracco, Bill Bellamy, Eagles Of Death Metal
- Episode 96: Cedric the Entertainer, Jason Bateman, Yoshi Amao
- Episode 97: Tim Robbins, Larry King, Lambchop
- Episode 98: Uma Thurman, Jon Favreau, Sugarcult
- Episode 99: Quentin Tarantino, Rhona Mitra, Ben Kweller
- Episode 100: Chris Rock, Shannon Elizabeth, Joe Buck
- Episode 101: David Duchovny, Kwame Jackson, Jim Gaffigan
- Episode 102: Rebecca Romijn-Stamos, Patton Oswalt, Shinedown
- Episode 103: Jennifer Esposito, Mark McKinney, David Feldman
- Episode 104: Tina Fey, Jamie Foxx, John Mayer
- Episode 105: Lindsay Lohan, Randy Jackson, Patti Smith
- Episode 106: Ray Liotta, Rachel Bilson, Carly Simon
- Episode 107: Andy Richter, Mila Kunis, Georges Brossard
- Episode 108: Brad Pitt, Janet Jackson
- Episode 109: Lauren Graham, Paula Abdul, Old Crow Medicine Show
- Episode 110: Eric Bana, Amy Poehler, Sondre Lerche
- Episode 111: Kelsey Grammer, Mariska Hargitay, Lewis Black
- Episode 112: Jimmy Fallon, Vince Curatola, Jamie Cullum
- Episode 113: Peter Gallagher, Pun Yin, Rachael Yamagata
- Episode 114: Laura Prepon, Robert Reich, Yellowcard
- Episode 115: Al Roker, Harland Williams, Manny Yarbrough
- Episode 116: Tom Selleck, Macaulay Culkin, Dave Attell
- Episode 117: Darrell Hammond, Benjamin McKenzie, Switchfoot
- Episode 118: Tom Arnold, Daniel Radcliffe, John Pizzarelli
- Episode 119: Brian Williams, Kevin Hart, Andrew W. K.
- Episode 120: Senator John McCain, George Lopez, Tom Papa
- Episode 121: Mandy Moore, Susie Essman, Ambulance, Ltd.
- Episode 122: Jay Mohr, Richard Schiff, Simple Kid
- Episode 123: Kristin Davis, Steve Coogan, Mama Gena
- Episode 124: Jennifer Love Hewitt, Steve Irwin, Indigo Girls
- Episode 125: Ice-T, Jeremy Suarez, Demetri Martin
- Episode 126: Jackie Chan, Tim Russert, Franz Ferdinand
- Episode 127: Matthew Broderick, Steven Wright, Patti Scialfa
- Episode 128: Tom Hanks, Sam Moore With Carla Thomas
- Episode 129: Gisele Bundchen, Jesse James, Auf Der Maur
- Episode 130: Ashley Judd, Jeff Goldblum, Alanis Morissette
- Episode 131: James Garner, Busy Phillips, Air Guitar Champion, Miri Park
- Episode 132: Marlon Wayans, Nicole Richie, Heart
- Episode 133: Michael Moore, Patton Oswalt, Ozomatli
- Episode 134: Will Ferrell, Beth Littleford, Jesse Malin
- Episode 135: Christina Applegate, Marc Maron, Sonic Youth
- Episode 136: John McEnroe, Sting
- Episode 137: Paul Rudd, Lars Ulrich, Jim Gaffigan
- Episode 138: Caroline Rhea, Jeff Garlin, Burning Brides
- Episode 139: Queen Latifah, Ali G, The Roots
- Episode 140: Alan Cumming, Vivica A. Fox, Ricky Fante
- Episode 141: Rev. Al Sharpton, Randy Constan
- Episode 142: Julianna Margulies, Kevin Pollak, Greg Fitzsimmons
- Episode 143: Benjamin Bratt, Isaac Mizrahi, Modest Mouse
- Episode 144: Halle Berry, Christopher Meloni, Erinn Smart
- Episode 145: Carson Daly, Laird Hamilton, D12
- Episode 146: Natalie Portman, Mark Consuelos, Los Lobos
- Episode 147: Jamie Foxx, Josie Maran, Beenie Man
- Episode 148: Brittany Murphy, John Cho, Louis C. K.
- Episode 149: Jada Pinkett Smith, Aries Spears, Sahara Hotnights
- Episode 150: Seth Green, Anne Hathaway, NOFX
- Episode 151: Clyde Peeling, Dax Shepard, Mutual Admiration Society
- Episode 152: Compilation Show
- Episode 153: Darrell Hammond, Blanchard Ryan, They Might Be Giants
Late Night with Conan O'Brien Season 11 Jay Mohr, Richard Schiff, Simple Kid
Stepping into the late-late slot vacated by David Letterman, Conan O'Brien stars in a show that far outdoes its competition in sheer strangeness. Along with the celebrity interviews and musical numbers typical of late-night talk shows, this program make frequent use of odd walk-on characters and frequent "visits" from celebrity guests.
